According to recent research from the United States, "We previously created a knock-in mutant mouse harboring a dominantly negative mutant thyroid hormone receptor beta (TR beta(PV/PV) mouse) that spontaneously develops a follicular thyroid carcinoma similar to human thyroid cancer. We found that beta-catenin, which plays a critical role in oncogenesis, was highly elevated in thyroid tumors of TR beta(PV/PV) mice."
"We sought to understand the molecular basis underlying aberrant accumulation of beta-catenin by mutations of TR beta in vivo. Cell-based studies showed that thyroid hormone (T3) induced the degradation of beta-catenin in cells expressing TR beta via …
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